PE-22-28 — illustrative photo of a kit of 10 vials — Illustrative packaging. Supplied materials and packaging vary by order.

Cognition & sleep · Research peptides

PE-22-28

Mini-Spadin TREK-1 research heptapeptide · evidence remains preclinical

Every lot ships with its COA — HPLC purity + MS identity
Purity specification ≥ 99.0%
From 1 kit (10 vials) per SKU
Written quote by email or WhatsApp

Specification

$60.95 / kit of 10 vials

$6.10 per vial · line total $60.95

kit · 10 vials

Need another spec, a larger fill or custom labelling?

Reference prices · PE-22-28 5 mg
Kits on your quote list	Price / kit
Retail · 1–4 kits	$60.95
Wholesale · 5–19 kits (−20%)	$48.76
20+ kits	Ask for a quote

Kits count across your whole quote list, so different products add up. Pricing FAQ

Reference prices in USD, per kit of 10 vials. The final price is the one on your written quote. Need another currency? Your sales representative can quote it.

Specifications

PE-22-28 parameters

CAS number	1801959-12-5
Molecular formula	C35H55N11O9
Molecular weight	773.9 g/mol
Sequence	GVSWGLR
PubChem CID	165437303
Purity specification	≥ 99.0% (HPLC)
Appearance	White to off-white lyophilized powder
Specifications	2 mg, 5 mg, 10 mg
Kit	10 vials per kit · minimum 1 kit per SKU
Storage	Follow the released-lot label, COA and stability data; do not assume generic refrigerated, frozen or reconstituted hold times.

Specifications and reference prices
SKU	Content	Price / kit	Per vial
`PE2`	2 mg	On request	—
`PE5`	5 mg	$60.95	$6.10
`PE10`	10 mg	$132.25	$13.23

Another format

PE-22-28 in a nasal spray bottle

Strengths: 10 mg
Fill: 10 mL or 20 mL
At least: 10 bottles of one strength and size
Dispatched from: US stock, to US addresses

Nasal sprays are quoted by our sales team, separately from the kits on your quote list.

Black 10 mL nasal spray bottle with a clear dust cap — Spray bottle, 10 mL

Test results for every lot

Each lot of PE-22-28 has its own certificate of analysis with HPLC purity and mass-spectrometry (MS) identity. Other tests — water content, counter-ion, endotoxin — are available on request and listed on the COA when tested.

Batch COAs 3

Batch COA, lot release

PE-22-28

2 mg

HPLC purity · MS identity

Batch COA, lot release

PE-22-28

5 mg

HPLC purity · MS identity

Batch COA, lot release

PE-22-28

10 mg

HPLC purity · MS identity

Previews show the first page only, at a resolution where small print cannot be read; numbers, dates, names and signatures are covered. The full, clear copy comes from our sales team.

COA of the batch you receive: ask our sales team.

Independent test fails? Full refund. How the refund works

How to read a COA →

Research background

About PE-22-28

A heptapeptide (GVSWGLR) derived from spadin, a fragment of the sortilin propeptide, connected with TREK-1 (KCNK2) potassium-channel and mood/neuroplasticity research.

This catalog entry is sourced from the reviewed SKU workbook. Available specifications, pack quantities, SKU identifiers, and prices are kept aligned with that source; lot-specific analytical documentation is available with the corresponding batch. Supplied strictly for laboratory research use.

Selected literature

Mazella J, Pétrault O, Lucas G, et al. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol. 2010;8(4):e1000355.
Djillani A, Pietri M, Moreno S, Heurteaux C, Mazella J, Borsotto M. Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity. Front Pharmacol. 2017;8:643.
Moha Ou Maati H, Veyssiere J, Labbal F, et al. Spadin as a new antidepressant: absence of TREK-1-related side effects. Neuropharmacology. 2012;62(1):278-288.
Pietri M, Djillani A, Mazella J, Borsotto M, Heurteaux C. First evidence of protective effects on stroke recovery and post-stroke depression induced by sortilin-derived peptides. Neuropharmacology. 2019;158:107715.
Djillani A, Pietri M, Mazella J, Heurteaux C, Borsotto M. Fighting against depression with TREK-1 blockers: Past and future. A focus on spadin. Pharmacol Ther. 2019;194:185-198.

For laboratory research use. This page describes published research and the material we supply; it is not medical advice.

How to order

Ordering PE-22-28 from Medabol

Kit and minimum: PE-22-28 is sold by the kit: 10 vials of one specification (2 mg, 5 mg and 10 mg). The minimum is 1 kit per SKU, so an individual buyer can order a single kit and a lab can order many.
Price: Reference prices are listed per kit above, from $60.95. The kits of your whole quote list count together — 5–19 kits are 20% off every kit, and from 20 kits our sales team quotes the price — so PE-22-28 adds up with anything else you order; your written quote has the final price.
Documents: Every lot has its own COA with HPLC purity and MS identity; the order ships with the certificate of its lot, and our sales team sends it before you order if you ask.
Shipping: Orders ship from China by international express courier. Shipping from $80 per order; the written quote confirms the exact charge for your destination.
Payment: Nothing is paid on this website. After you send your quote list, a sales representative confirms the amount and shipping on WhatsApp or by email and tells you in that chat how to pay.
Research goal: Listed under Cognition & sleep — Neuropeptides such as Semax, Selank, DSIP and Pinealon.

Questions first?

Ask about PE-22-28.

Quantities, documents, timing or a spec that is not listed — the reply comes from a sales representative.

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PE-22-28

PE-22-28 parameters

PE-22-28 in a nasal spray bottle

Test results for every lot

Batch COAs 3

PE-22-28

PE-22-28

PE-22-28

About PE-22-28

Selected literature

Ordering PE-22-28 from Medabol

Ask about PE-22-28.

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